The core structural element of a majority of naturally-occurring and disease-related amyloid fibrils is a β-arcade representing a parallel and in register stacks of β-strand-loop-β-strand motifs called β-arches (reviewed in Kajava et al. FASEB J. 2010 24:1311). "ArchCandy" was developed based on an assumption that protein sequences that are able to form β-arcades are amyloidogenic.
This program allows :
- to distinguish between amyloidogenic and non-amyloidogenic sequences
- to localize the amyloidogenic regions within the protein
- to explain the effect of mutations on the amyloid forming potential
- to predict the 3D structures of amyloid fibrils.
Ahmed A.B., Znassi N., Château M.T. and Kajava A.V.
A structure-based approach to predict predisposition to amyloidosis. (2015)
Alzheimers & Dementia 11(6):681-690.